With the collaboration of
Con la colaboración de

Program

12:00-15:30

Registration and posters set-up

12:30-12:45

Welcome Ceremony

Dña. Marina Pollán Santamaría, Directora del Instituto de Salud Carlos III

D. Manuel Sánchez de la Torre, Director Científico del Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM)

D. Ricardo Cuevas Campos, Vicerrector de Política Científica de la Universidad de Castilla-La Mancha

D. Javier Lopez Martín, Presidente de Eurocaja Rural

Dña. Marta Ortiz Rivera, Subdirectora General de Redes y Centros de Investigación Cooperativa del ISCIII

12:45-13:45

Colloquium with representatives of patient advocacy organizations

CHAIRPERSONS: Adolfo López de Munain / Pedro Abizanda

Dña. Inés Losa, Plataforma de Organizaciones de Pacientes (POP)

Dña. M. Dolores Almagro Cabrera, Confederación Española de Alzheimer (CEAFA)

Dña. Begoña Martín, Federación Española de Enfermedades Neuromusculares (ASEM)

Dña. Beatriz Martínez de la Cruz, Esclerosis Múltiple España (EME)

D. Antonio Burgueño, Confederación Española de Organizaciones de Mayores (CEOMA)

13:45-15:30

Welcome cocktail, networking & posters view

15:30-17:15

Neuroinflammation and neurodegeneration I

CHAIRPERSON: Pablo Mir

15:30-16:15

“Innate immunity in neurodegenerative disease”

Michael T. Heneka, Luxembourg Centre for Systems Biomedicine, University of Luxembourg

16:15-16:40

“Role of CD8 T cells in the onset of Parkinson’s disease”

Jordi Bové, CIBERNED, Vall d'Hebron Research Institute, Barcelona, Spain

16:40-17:05

“Exploring the link between peripheral inflammation and Parkinson’s disease”

Laura Muñoz Delgado, CIBERNED, Institute of Biomedicine of Seville (IBiS), Spain

17:05-17:45

Coffee break, networking & posters view

17:45-19:25

Therapeutic approaches and biomarkers

CHAIRPERSON: Eva Carro

17:45-18:10

“Usefulness of genistein to delay the transition from minimal cognitive impairment to Alzheimer’s dementia research”

José Viña, CIBERFES, University of Valencia, Institute of Health Research-INCLIVA, Valencia, Spain

18:10-18:35

“Alpha-synuclein targeted CAR-Treg cell therapy”

Alfonso Rodríguez-Gil, CIBERNED, Institute of Biomedicine of Seville (IBiS), Spain)

18:35-19:00

“Melatonin and cognitive decline”

Germaine Escames, CIBERFES, University of Granada, Spain

19:00-19:25

“CIEN: A Unique Hub for Neurodegenerative Biomarker Discovery”

Pascual Sánchez-Juan, CIBERNED, Alzheimer's Centre Reina Sofía-CIEN Foundation, Madrid, Spain

19:25-19:40

“NULISA Technology a new ultra-sensitive proteomics platform for profiling CNS fluid-based biomarkers”

Barry Lynch, Alamar Biosciences, Fremont, CA, USA

9:00 - 11:00

Young Investigator Awards & Poster Highlights

CHAIRPERSON: Teresa Iglesias

09:00

“Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality”

Nicolás Capelo, Young Investigator Award, CIBERNED, Institute of Biomedicine of Seville (IBiS), Spain

09:20

“Biallelic variants in SNUPN cause a limb girdle muscular dystrophy with myofibrillar-like features”

Pablo Iruzubieta, Clinical Young Investigator Award, CIBERNED, Montreal Neurological Institute, Toronto, Canada

09:40

Short communications from selected posters

“Age-dependent progression from clearance to vulnerability of microglia to αSyn toxic species

Salomé Sirerol, CIBERNED, University of Valencia

“ATP synthase reverse activity emerges as a new metabolic indicator of aging”

Rebeca Acín, CIBERFES, National Center for Cardiovascular Research

“Cellular senescence: the missing link between aging and Alzheimer’s Disease?”

Ana Guerero, CIBERNED, University of Barcelona

“Application of Volume Electron Microscopy to the Study of Alzheimer’s Disease”

Marta Turégano, CIBERNED, Technical University of Madrid

“Age-related changes in the excitatory translatome of Alzheimer’s disease transgenic mice”

Arnaldo Parra, CIBERNED, Autonomous University of Barcelona

“Multicenter cluster randomized clinical trial to analyze the efficacy of the Spanish National Health System Prevention Strategy-based intervention to improve frailty or physical function in prefrail or frail older adults: THE FRAILMERIT STUDY”

Almudena Avendaño, CIBERFES, University of Castilla-La Mancha, Albacete, Spain

“Mice overexpressing mutated profilin 1 (PFN1 G118V) recapitulate motor, neuromuscular and cognitive ALS/FTD phenotype”

Assumpció Bosch, CIBERNED, Autonomous University of Barcelona

“Myelin-derived fatty acids fuel brain neurons and glia in health and disease”

Eneritz López, CIBERNED, University of the Basque Country

11:00 – 11:30

Coffee break, networking & posters view

11:30 - 13:30

CIBERFES BOARD OF PIs (parallel session, Lounge Carolina, first floor)

11:30-13:30

Neuroinflammation and neurodegeneration II

CHAIRPERSON: Isabel Fariñas

11:30-12:10

“Encephalitis and neurodegeneration caused by synaptic autoimmunity”

Josep Dalmau, Hospital Clínic de Barcelona, University of Barcelona, Spain

12:10-12:35

“Humanized preclinical models to study glial pathology and remyelination strategies in multiple sclerosis patients”

Andrés Miguez, CIBERNED, Vall d'Hebron University Hospital, Barcelona, Spain

12:35-13:00

“Leveraging magnetic resonance image to understand microstructural brain trajectories in ageing and Alzheimer”

Silvia de Santis, Institute for Neuroscience, Alicante, Spain

13:00- 15:00

Lunch, networking & posters view

15:15-16:30

Aging, frailty and neurodegeneration I

CHAIRPERSON: Leocadio Rodríguez Mañas

15:15-15:40

“Exploring the Brain-Microbiota-Gut Axis: Metabolomic Bridges Between Nutrition and Healthy Aging”

Cristina Andrés Lacueva, CIBERFES, University of Barcelona, Spain

15:40-16:05

“Neuromuscular changes with frailty and sarcopenia”

María Carmen Gómez-Cabrera, CIBERFES, University of Valencia. Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain

16:05:16:30

“Frailty, cognitive impairment and dementia”

Francisco José García, CIBERFES, University Hospital Complex, Toledo, Spain

16:30 – 17:00

Coffee break & posters

17:00 - 18:15

Aging, frailty and neurodegeneration II

CHAIRPERSON: José Viña

17:00-17:25

“Exploring the links between aging, neurodegeneration and orphan ribosomal proteins”

Oscar Fernández-Capetillo, CIBERNED, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

17:25-17:50

“Functional and structural longitudinal brain trajectories in superaging”

Bryan A. Strange, Center of Biomedical technology, Technical University of Madrid, Spain

17:50-18:15

“Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research (SEED-ALS)”

Carmen Paradas, CIBERNED, Institute of Biomedicine of Seville (IBiS), Spain

18:30 - 19:30

CIBERNED BOARD OF PIs

18:30 - 19:30

YOUNG INVESTIGATORS MEETING (parallel session, Lounge Carolina)

9:00 - 11:00

Neuroinflammation and neurodegeneration III

CHAIRPERSON: Manuel Comabella

09:00-09:25

“Central and Peripheral Immunity in Parkinson's Disease and Prodromal Forms”

M. Cruz Rodríguez-Oroz, University Clinic of Navarra, Pamplona, Spain

09:25-09:50

“The astrocyte-neuron interaction in the modulation of brain activity. Pathological implications”

Juan P. Bolaños, CIBERFES, Institute of Functional Biology and Genomics, CSIC, University of Salamanca, Spain

09:50-10:15

“Role of astrocytes in physiological and pathological brain aging”

Ander Matheu, CIBERFES, Biogipuzkoa Institute for Health Research, Spain

10:15-11:00

PhD blitz session 1

CHAIRPERSON: Patricia Gómez-Suaga

“Aging-dependent immunological changes in multiple sclerosis”

Andrea Iribarren, CIBERNED, Biogipuzkoa Health Research Institute, PhD supervisor:D. Otaegui and A. Albarro

“Alteraciones de las vías endocítica-lisosomal y el metabolismo energético en la distrofia miotónica tipo 1”

Eva Alegre, CIBERNED, University of Extremadura, PhD supervisors: J.M. Fuentes and S. Yakhine Diop

“Defining the role of transcription factor NRF2 in the maintenance of synaptic homeostasis”

Daniel Carnicero, CIBERNED, Autonomous University of Madrid, PhD supervisor: A.I. Rojo

“Alteraciones fenotípicas en ratones carentes del complejo I mitocondrial en astrocitos.”

Mª Luisa Hidalgo, CIBERFES, Institute of Functional Biology and Genomics, PhD supervisor: J.P. Bolaños

“Role of cholesterol in HSV-1-induced infection and neurodegeneration in 3D human neural cultures”

Blanca Salgado, CIBERNED, Autonomous University of Madrid, PhD supervisors: M.J. Bullido and J. Aldudo

“Las células mieloides supresoras como biomarcador de la capacidad endógena de remielinización en Esclerosis Múltiple”

María Cabañas, CIBERNED, National Hospital for Paraplegics, PhD supervisor: D. Clemente

“Relationships between Different Neurodegeneration Biomarkers and Cognitive Decline Trajectories in a Preclinical Alzheimer’s Cohort"

Anna Coward, CIBERFES, Barcelonabeta Brain Research Center, PhD supervisors: O. Grau, M. Suárez Calvet, and G. Salvadó Blasco

“Vascular Endothelial Growth Factor (VEGF) in the Oculomotor System: Presence and Modulation After Injury.””

Silvia Silva, CIBERNED, Institute of Biomedicine of Seville, PhD supervisor: S. Morcuende

“Search for new drugs for Dementia with Lewy Bodies and other dementias”

Lucía Baselga, CIBERNED, Center of Biological Research CSIC, PhD supervisor: A. Martínez

11:00 - 11:30

Coffee break & posters view

11:30-12:15

PhD blitz session 2

CHAIRPERSON: Cristina Ortega

“Papel de QBA en Envejecimiento y Neurodegeneración”

Marta Paredes, CIBERNED, University of Extremadura, PhD supervisor: M. Niso and G. Martínez

“The role of metabolic time in circadian health”

Pedro González, CIBERFES, University of Murcia, PhD supervisors: M.A. Rol de Lama and J.A. Madrid

“El papel de los ARN no codificantes en la progresión de Deterioro Cognitivo Leve a demencia”

Nora Molina, CIBERNED, University of Zaragoza, PhD supervisor: R. Osta

“Descifrando el impacto del sexo en el perfil proteómico de la demencia”

Aina Comas, CIBERNED, Clinic Hospital of Barcelona, PhD Supervisor: R. Sánchez-Valle

“Pathological ATAD3 variants and perturbed cholesterol metabolism in human and fly”

Mikel Muñoz, CIBERNED, Biogipuzkoa Health Research Institute, PhD supervisor: I. Holt and I. Martí

“Ribosomopathies at the core of aging and neurodegeneration”

Anabel Sáez, CIBERNED, National Cancer Research Institute, Ph D supervisor: O. Fernández-Capetillo

“Salivary lactoferrin as a new Alzheimer’s disease non-invasive biomarker: link between oral dysbiosis and infective hypothesis”

Deborah Romualdi, CIBERNED, Carlos III Health Institute, PhD supervisor: E. Carro

“NRF2 deficiency exacerbates stress granule persistence and protein aggregation in ALS”

José Jiménez, CIBERNED, Autonomous University of Madrid, PhD supervisor: A. Cuadrado and A.I. Rojo

“Impact of the mitochondrial pyruvate carrier on astrocytic metabolism and mouse physiology”

Darío García, CIBERFES, Institute of Functional Biology and Genomics, PhD supervisor: J.P. Bolaños

11:30 – 13:30

Neuroinflammation and neurodegeneration IV

CHAIRPERSON: Carlos Matute

12:15 – 12:40

“New neuroimmunological insights into disease severity in multiple sclerosis: implications for myelin repair”

Diego Clemente, CIBERNED, National Hospital for Paraplegics, Toledo, Spain

12:40-13:05

“Microglial modulation of astrocyte metabolism in Alzheimer's disease”

Clara Muñoz-Castro, CIBERNED,Institute of Biomedicine of Seville, Spain

13:05-13:30

“Non coding RNA in Multiple Sclerosis”

David Otaegui, CIBERNED, Biogipuzkoa Institute for Health Research, Spain

13:30

Summary and concluding remarks. Farewell